Reciprocal feedback inhibition of the androgen receptor and PI3K as a novel therapy for castrate-sensitive and -resistant prostate cancer

Gain-of-function of the androgen receptor (AR) and activation of PI3K/AKT/mTOR pathway have been demonstrated to correlate with progression to castration-resistant prostate cancer (CRPC). However, inhibition of AR or PI3K/mTOR alone results in a reciprocal feedback activation. Therefore, we hypothes...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Qi, Wenqing, Morales, Carla, Cooke, Laurence S., Johnson, Benny, Somer, Bradley, Mahadevan, Daruka
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747202/
https://ncbi.nlm.nih.gov/pubmed/26506516
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