5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits

Despite marked tumor shrinkage after 5-FU treatment, the frequency of colon cancer relapse indicates that a fraction of tumor cells survives treatment causing tumor recurrence. The majority of cancer cells divert metabolites into anabolic pathways through Warburg behavior giving an advantage in term...

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Publicado en:Oncotarget
Autores principales: Denise, Corti, Paoli, Paolo, Calvani, Maura, Taddei, Maria Letizia, Giannoni, Elisa, Kopetz, Scott, Kazmi, Syed Mohammad Ali, Pia, Morelli Maria, Pettazzoni, Piergiorgio, Sacco, Elena, Caselli, Anna, Vanoni, Marco, Landriscina, Matteo, Cirri, Paolo, Chiarugi, Paola
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747183/
https://ncbi.nlm.nih.gov/pubmed/26527315
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