Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread

Cancer associated fibroblasts (CAFs) are key determinants of cancer progression. In prostate carcinoma (PCa), CAFs induce epithelial-mesenchymal transition (EMT) and metabolic reprogramming of PCa cells towards oxidative phosphorylation (OXPHOS), promoting tumor growth and metastatic dissemination....

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Vydáno v:Oncotarget
Hlavní autoři: Giannoni, Elisa, Taddei, Maria Letizia, Morandi, Andrea, Comito, Giuseppina, Calvani, Maura, Bianchini, Francesca, Richichi, Barbara, Raugei, Giovanni, Wong, Nicholas, Tang, Damu, Chiarugi, Paola
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2015
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4695170/
https://ncbi.nlm.nih.gov/pubmed/26183399
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