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Time-Dependent Stabilization of Hypoxia Inducible Factor-1α by Different Intracellular Sources of Reactive Oxygen Species

Intratumoral hypoxia is a major obstacle in the development of effective cancer chemotherapy, decreasing the efficacy of anti-neoplastic drugs in several solid tumours. The hypoxic environment, through its master regulator hypoxia inducible factor-1 (HIF-1), is able to maintain an anti-apoptotic pot...

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書誌詳細
主要な著者: Calvani, Maura, Comito, Giuseppina, Giannoni, Elisa, Chiarugi, Paola
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3483303/
https://ncbi.nlm.nih.gov/pubmed/23144690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038388
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