Mutant p53 confers chemoresistance in non-small cell lung cancer by upregulating Nrf2

Nrf2 is a key transcription factor for genes coding for antioxidants, detoxification enzymes, and multiple drug resistance and it also confers resistance to anticancer drugs. Here, we hypothesized that mutant p53 could upregulate Nrf2 expression at the transcriptional level, thereby conferring cispl...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Tung, Min-Che, Lin, Po-Lin, Wang, Yao-Chen, He, Tsung-Ying, Lee, Ming-Ching, Yeh, Sauh-Der, Chen, Chih-Yi, Lee, Huei
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747182/
https://ncbi.nlm.nih.gov/pubmed/26497680
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