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Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph(+) leukemia

BACKGROUND: Proteostasis is defined by the orchestrated control of anabolic and catabolic protein pathways. Disruption of proteostasis results in cell stress and adaptation to proteostasis imbalance is mediated by adaptive pathways such as the Heat Shock Response (including heat-shock proteins) or t...

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Detalhes bibliográficos
Publicado no:Exp Hematol Oncol
Main Authors: Vieri, Margherita, Geng, Huimin, Patterson, John B., Panse, Jens, Wilop, Stefan, Samali, Afshin, Chevet, Eric, Masouleh, Behzad Kharabi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746784/
https://ncbi.nlm.nih.gov/pubmed/26862466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40164-016-0034-5
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