Small-molecule inhibition of PTPRZ reduces tumor growth in a rat model of glioblastoma

Protein tyrosine phosphatase receptor-type Z (PTPRZ) is aberrantly over-expressed in glioblastoma and a causative factor for its malignancy. However, small molecules that selectively inhibit the catalytic activity of PTPRZ have not been discovered. We herein performed an in vitro screening of a chem...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Fujikawa, Akihiro, Nagahira, Asako, Sugawara, Hajime, Ishii, Kentaro, Imajo, Seiichi, Matsumoto, Masahito, Kuboyama, Kazuya, Suzuki, Ryoko, Tanga, Naomi, Noda, Masanori, Uchiyama, Susumu, Tomoo, Toshiyuki, Ogata, Atsuto, Masumura, Makoto, Noda, Masaharu
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746629/
https://ncbi.nlm.nih.gov/pubmed/26857455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep20473
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