NudC regulates actin dynamics and ciliogenesis by stabilizing cofilin 1

Emerging data indicate that actin dynamics is associated with ciliogenesis. However, the underlying mechanism remains unclear. Here we find that nuclear distribution gene C (NudC), an Hsp90 co-chaperone, is required for actin organization and dynamics. Depletion of NudC promotes cilia elongation and...

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Bibliografiske detaljer
Udgivet i:Cell Res
Main Authors: Zhang, Cheng, Zhang, Wen, Lu, Yi, Yan, Xiaoyi, Yan, Xiumin, Zhu, Xueliang, Liu, Wei, Yang, Yuehong, Zhou, Tianhua
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746604/
https://ncbi.nlm.nih.gov/pubmed/26704451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2015.152
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