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Engineering CAR-T Cells: Design Concepts
Despite being empirically designed based on a simple understanding of TCR signaling, T cells engineered with chimeric antigen receptors (CARs) have been remarkably successful in treating patients with advanced refractory B cell malignancies. However, many challenges remain in improving the safety an...
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| Publié dans: | Trends Immunol |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4746114/ https://ncbi.nlm.nih.gov/pubmed/26169254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2015.06.004 |
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