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Engineering CAR-T Cells: Design Concepts
Despite being empirically designed based on a simple understanding of TCR signaling, T cells engineered with chimeric antigen receptors (CARs) have been remarkably successful in treating patients with advanced refractory B cell malignancies. However, many challenges remain in improving the safety an...
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| Publicado no: | Trends Immunol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4746114/ https://ncbi.nlm.nih.gov/pubmed/26169254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.it.2015.06.004 |
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