Phase II Study of Olaparib (AZD-2281) After Standard Systemic Therapies for Disseminated Colorectal Cancer

BACKGROUND. Effective new agents for patients with colorectal cancer (CRC) with disease progression during standard therapy regimens are needed. We hypothesized that poly ADP ribose polymerase (PARP) inhibitor therapy in patients with CRC and inefficient tumor DNA repair mechanisms, such as those wi...

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Bibliografiske detaljer
Udgivet i:Oncologist
Main Authors: Leichman, Lawrence, Groshen, Susan, O’Neil, Bert H., Messersmith, Wells, Berlin, Jordan, Chan, Emily, Leichman, Cynthia G., Cohen, Steven J., Cohen, Deirdre, Lenz, Heinz-Josef, Gold, Philip, Boman, Bruce, Fielding, Anitra, Locker, Gershon, Cason, Ronald C., Hamilton, Stan R., Hochster, Howard S.
Format: Artigo
Sprog:Inglês
Udgivet: AlphaMed Press 2016
Fag:
Gastrointestinal Cancer
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4746089/
https://ncbi.nlm.nih.gov/pubmed/26786262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2015-0319
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