CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

Cathepsins S (CatS) has been implicated in numerous tumourigenic processes and here we document for the first time its involvement in CCL2 regulation within the tumour microenvironment. Analysis of syngeneic tumours highlighted reduced infiltrating macrophages in CatS depleted tumours. Interrogation...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wilkinson, Richard D.A., Magorrian, Sinead M., Williams, Rich, Young, Andrew, Small, Donna M., Scott, Christopher J., Burden, Roberta E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745758/
https://ncbi.nlm.nih.gov/pubmed/26358505
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