CCL2 is transcriptionally controlled by the lysosomal protease cathepsin S in a CD74-dependent manner

Cathepsins S (CatS) has been implicated in numerous tumourigenic processes and here we document for the first time its involvement in CCL2 regulation within the tumour microenvironment. Analysis of syngeneic tumours highlighted reduced infiltrating macrophages in CatS depleted tumours. Interrogation...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Wilkinson, Richard D.A., Magorrian, Sinead M., Williams, Rich, Young, Andrew, Small, Donna M., Scott, Christopher J., Burden, Roberta E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745758/
https://ncbi.nlm.nih.gov/pubmed/26358505
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