Metformin represses cancer cells via alternate pathways in N-cadherin expressing vs. N-cadherin deficient cells

Metformin has emerged as a potential anticancer agent. Here, we demonstrate that metformin plays an anti-tumor role via repressing N-cadherin, independent of AMPK, in wild-type N-cadherin cancer cells. Ectopic-expression of N-cadherin develops metformin-resistant cancer cells, while suppression of N...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Ge, Rongbin, Wang, Zongwei, Wu, Shulin, Zhuo, Yangjia, Otsetov, Aleksandar G., Cai, Chao, Zhong, Weide, Wu, Chin-Lee, Olumi, Aria F.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745705/
https://ncbi.nlm.nih.gov/pubmed/26359363
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