PI3K/AKT signaling modulates transcriptional expression of EWS/FLI1 through specificity protein 1

Ewing sarcoma (ES) is the second most frequent bone cancer in childhood and is characterized by the presence of the balanced translocation t(11;22)(q24;q12) in more than 85% of cases, generating a dysregulated transcription factor EWS/FLI1. This fusion protein is an essential oncogenic component of...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Giorgi, Chiara, Boro, Aleksandar, Rechfeld, Florian, Lopez-Garcia, Laura A., Gierisch, Maria E., Schäfer, Beat W., Niggli, Felix K.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745699/
https://ncbi.nlm.nih.gov/pubmed/26336820
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