The length distribution of class I restricted T cell epitopes is determined by both peptide supply and MHC allele specific binding preference

HLA class I binding predictions are widely used to identify candidate peptide targets of human CD8+ T cell responses. Many such approaches focus exclusively on a limited range of peptide lengths, typically 9 and sometimes 9-10 amino acids, despite multiple examples of dominant epitopes of other leng...

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Veröffentlicht in:J Immunol
Hauptverfasser: Trolle, Thomas, McMurtrey, Curtis P., Sidney, John, Bardet, Wilfried, Osborn, Sean C., Kaever, Thomas, Sette, Alessandro, Hildebrand, William H., Nielsen, Morten, Peters, Bjoern
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744552/
https://ncbi.nlm.nih.gov/pubmed/26783342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501721
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