Memory Stem T Cells in Autoimmune Disease: High Frequency of Circulating CD8(+) Memory Stem Cells in Acquired Aplastic Anemia

Memory stem T cells (TSCMs) constitute a long-lived, self-renewing lymphocyte population essential for the maintenance of functional immunity. Hallmarks of autoimmune disease pathogenesis are abnormal CD4(+) and CD8(+) T cell activation. We investigated the TSCM subset in 55, 34, 43, and 5 patients...

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Publicat a:J Immunol
Autors principals: Hosokawa, Kohei, Muranski, Pawel, Feng, Xingmin, Townsley, Danielle M., Liu, Baoying, Knickelbein, Jared, Keyvanfar, Keyvan, Dumitriu, Bogdan, Ito, Sawa, Kajigaya, Sachiko, Taylor, James G., Kaplan, Mariana J., Nussenblatt, Robert B., Barrett, A. John, O’Shea, John, Young, Neal S.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744506/
https://ncbi.nlm.nih.gov/pubmed/26764034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1501739
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