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Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma

Aberrant expression of cancer genes and non-canonical RNA species is a hallmark of cancer. However, the mechanisms driving such atypical gene expression programs are incompletely understood. Here, our transcriptional profiling of a cohort of 50 primary clear cell renal cell carcinoma (ccRCC) samples...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Grosso, Ana R, Leite, Ana P, Carvalho, Sílvia, Matos, Mafalda R, Martins, Filipa B, Vítor, Alexandra C, Desterro, Joana MP, Carmo-Fonseca, Maria, de Almeida, Sérgio F
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744188/
https://ncbi.nlm.nih.gov/pubmed/26575290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.09214
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