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Crystal structures and inhibition kinetics reveal a two-stage catalytic mechanism with drug design implications for rhomboid proteolysis
Intramembrane proteases signal by releasing proteins from the membrane, but despite their importance their enzymatic mechanisms remain obscure. We probed rhomboid proteases with reversible, mechanism-based inhibitors that allow precise kinetic analysis, and faithfully mimic the transition-state stru...
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| Wydane w: | Mol Cell |
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| Główni autorzy: | , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2016
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4744120/ https://ncbi.nlm.nih.gov/pubmed/26805573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.12.022 |
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