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FBXW7 facilitates non-homologous end-joining via K63-linked polyubiquitylation of XRCC4
FBXW7 is a haploinsufficient tumor suppressor with loss-of-function mutations occurring in human cancers. FBXW7 inactivation causes genomic instability, yet the mechanism remains elusive. Here we show that FBXW7 facilitates non-homologous end-joining (NHEJ) repair and FBXW7 depletion causes radiosen...
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| Publicado no: | Mol Cell |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4744117/ https://ncbi.nlm.nih.gov/pubmed/26774286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.12.010 |
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