Constitutively Active MAVS Inhibits HIV-1 Replication via Type I Interferon Secretion and Induction of HIV-1 Restriction Factors

Type I interferon is known to inhibit HIV-1 replication through the induction of interferon stimulated genes (ISG), including a number of HIV-1 restriction factors. To better understand interferon-mediated HIV-1 restriction, we constructed a constitutively active form of the RIG-I adapter protein MA...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gupta, Sachin, Termini, James M., Issac, Biju, Guirado, Elizabeth, Stone, Geoffrey W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743994/
https://ncbi.nlm.nih.gov/pubmed/26849062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148929
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