Postnatal Deletion of the Type II TGF-Beta Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice

OBJECTIVE: Prenatal deletion of the type II TGF-β receptor (TBRII) prevents normal vascular morphogenesis and smooth muscle cell (SMC) differentiation, causing embryonic death. The role of TBRII in adult SMC is less well studied. Clarification of this role has important clinical implications because...

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Publicado no:Arterioscler Thromb Vasc Biol
Main Authors: Hu, Jie Hong, Wei, Hao, Jaffe, Mia, Airhart, Nathan, Du, Liang, Angelov, Stoyan N., Yan, James, Allen, Julie K., Kang, Inkyung, Wight, Thomas, Fox, Kate, Smith, Alexandra, Enstrom, Rachel, Dichek, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743752/
https://ncbi.nlm.nih.gov/pubmed/26494233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306573
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