Postnatal Deletion of the Type II TGF-Beta Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice

OBJECTIVE: Prenatal deletion of the type II TGF-β receptor (TBRII) prevents normal vascular morphogenesis and smooth muscle cell (SMC) differentiation, causing embryonic death. The role of TBRII in adult SMC is less well studied. Clarification of this role has important clinical implications because...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Hu, Jie Hong, Wei, Hao, Jaffe, Mia, Airhart, Nathan, Du, Liang, Angelov, Stoyan N., Yan, James, Allen, Julie K., Kang, Inkyung, Wight, Thomas, Fox, Kate, Smith, Alexandra, Enstrom, Rachel, Dichek, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743752/
https://ncbi.nlm.nih.gov/pubmed/26494233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306573
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