Intracellular mGluR5 plays a critical role in neuropathic pain

Spinal mGluR5 is a key mediator of neuroplasticity underlying persistent pain. Although brain mGluR5 is localized on cell surface and intracellular membranes, neither the presence nor physiological role of spinal intracellular mGluR5 is established. Here we show that in spinal dorsal horn neurons &g...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Vincent, Kathleen, Cornea, Virginia M., Jong, Yuh-Jiin I., Laferrière, André, Kumar, Naresh, Mickeviciute, Aiste, Fung, Jollee S. T., Bandegi, Pouya, Ribeiro-da-Silva, Alfredo, O'Malley, Karen L., Coderre, Terence J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742982/
https://ncbi.nlm.nih.gov/pubmed/26837579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10604
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