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Effect of the Plant Derivative Compound A on the Production of Corticosteroid-Resistant Chemokines in Airway Smooth Muscle Cells

Preclinical models of human conditions including asthma showed the therapeutic potential of Compound A (CpdA), a dissociated glucocorticoid (GC) receptor (GRα) ligand. Whether CpdA inhibits GC resistance, a central feature of severe asthma, has not been addressed. We investigated whether CpdA modula...

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Detalles Bibliográficos
Publicado en:Am J Respir Cell Mol Biol
Main Authors: Gavrila, Adelina, Chachi, Latifa, Tliba, Omar, Brightling, Christopher, Amrani, Yassine
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742953/
https://ncbi.nlm.nih.gov/pubmed/25897650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2014-0477OC
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