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Amino acid changes in PB2 and HA affect the growth of a recombinant influenza virus expressing a fluorescent reporter protein

Influenza viruses that express reporter proteins are useful tools, but are often attenuated. Recently, we found that an influenza virus encoding the Venus fluorescent protein acquired two mutations in its PB2 and HA proteins upon mouse adaptation. Here, we demonstrate that the enhanced viral replica...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Katsura, Hiroaki, Fukuyama, Satoshi, Watanabe, Shinji, Ozawa, Makoto, Neumann, Gabriele, Kawaoka, Yoshihiro
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742795/
https://ncbi.nlm.nih.gov/pubmed/26847414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19933
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