Reactive Center Loop (RCL) Peptides Derived from Serpins Display Independent Coagulation and Immune Modulating Activities

Serpins regulate coagulation and inflammation, binding serine proteases in suicide-inhibitory complexes. Target proteases cleave the serpin reactive center loop scissile P1–P1′ bond, resulting in serpin-protease suicide-inhibitory complexes. This inhibition requires a near full-length serpin sequenc...

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Sparad:
Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Ambadapadi, Sriram, Munuswamy-Ramanujam, Ganesh, Zheng, Donghang, Sullivan, Colin, Dai, Erbin, Morshed, Sufi, McFadden, Baron, Feldman, Emily, Pinard, Melissa, McKenna, Robert, Tibbetts, Scott, Lucas, Alexandra
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Immunology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742751/
https://ncbi.nlm.nih.gov/pubmed/26620556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.704841
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