Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism

Drug discovery opportunities where loss-of-function alleles of a target gene link to a disease-relevant phenotype often require an agonism approach to up-regulate or re-establish the activity of the target gene. Antibody therapy is increasingly recognized as a favored drug modality due to multiple d...

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Udgivet i:J Biol Chem
Main Authors: Gunawardane, Ruwanthi N., Fordstrom, Preston, Piper, Derek E., Masterman, Stephanie, Siu, Sophia, Liu, Dongming, Brown, Mike, Lu, Mei, Tang, Jie, Zhang, Richard, Cheng, Janet, Gates, Andrew, Meininger, David, Chan, Joyce, Carlson, Tim, Walker, Nigel, Schwarz, Margrit, Delaney, John, Zhou, Mingyue
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742745/
https://ncbi.nlm.nih.gov/pubmed/26644477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.672790
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