Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism

Drug discovery opportunities where loss-of-function alleles of a target gene link to a disease-relevant phenotype often require an agonism approach to up-regulate or re-establish the activity of the target gene. Antibody therapy is increasingly recognized as a favored drug modality due to multiple d...

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Publicado en:J Biol Chem
Autores principales: Gunawardane, Ruwanthi N., Fordstrom, Preston, Piper, Derek E., Masterman, Stephanie, Siu, Sophia, Liu, Dongming, Brown, Mike, Lu, Mei, Tang, Jie, Zhang, Richard, Cheng, Janet, Gates, Andrew, Meininger, David, Chan, Joyce, Carlson, Tim, Walker, Nigel, Schwarz, Margrit, Delaney, John, Zhou, Mingyue
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742745/
https://ncbi.nlm.nih.gov/pubmed/26644477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.672790
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