Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases

The KDM5/JARID1 family of Fe(II)- and α-ketoglutarate-dependent demethylases remove methyl groups from tri- and dimethylated lysine 4 of histone H3. Accumulating evidence from primary tumors and model systems supports a role for KDM5A (JARID1A/RBP2) and KDM5B (JARID1B/PLU1) as oncogenic drivers. The...

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Udgivet i:J Biol Chem
Main Authors: Horton, John R., Engstrom, Amanda, Zoeller, Elizabeth L., Liu, Xu, Shanks, John R., Zhang, Xing, Johns, Margaret A., Vertino, Paula M., Fu, Haian, Cheng, Xiaodong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742734/
https://ncbi.nlm.nih.gov/pubmed/26645689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.698449
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