High-density lipoprotein modulates thrombosis by preventing von Willebrand factor self-association and subsequent platelet adhesion

The ability of von Willebrand factor (VWF) to initiate platelet adhesion depends on the number of monomers in individual VWF multimers and on the self-association of individual VWF multimers into larger structures. VWF self-association is accelerated by shear stress. We observed that VWF self-associ...

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Publicado en:Blood
Autores principales: Chung, Dominic W., Chen, Junmei, Ling, Minhua, Fu, Xiaoyun, Blevins, Teri, Parsons, Scott, Le, Jennie, Harris, Jeff, Martin, Thomas R., Konkle, Barbara A., Zheng, Ying, López, José A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2016
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742551/
https://ncbi.nlm.nih.gov/pubmed/26552698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-09-599530
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