Signaling-mediated cooperativity between glycoprotein Ib-IX and protease-activated receptors in thrombin-induced platelet activation

Thrombin-induced cellular response in platelets not only requires protease-activated receptors (PARs), but also involves another thrombin receptor, the glycoprotein Ib-IX complex (GPIb-IX). It remains controversial how thrombin binding to GPIb-IX stimulates platelet responses. It was proposed that G...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: Estevez, Brian, Kim, Kyungho, Delaney, M. Keegan, Stojanovic-Terpo, Aleksandra, Shen, Bo, Ruan, Changgeng, Cho, Jaehyung, Ruggeri, Zaverio M., Du, Xiaoping
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2016
Schlagworte:
Platelets and Thrombopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742550/
https://ncbi.nlm.nih.gov/pubmed/26585954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-638387
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