LXRα improves myocardial glucose tolerance and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes

AIMS/HYPOTHESIS: Diabetic cardiomyopathy is a myocardial disease triggered by impaired insulin signalling, increased fatty acid uptake and diminished glucose utilisation. Liver X receptors (LXRs) are key transcriptional regulators of metabolic homeostasis. However, their effect in the diabetic heart...

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Pubblicato in:Diabetologia
Autori principali: Cannon, Megan V., Silljé, Herman H. W., Sijbesma, Jürgen W. A., Khan, Mohsin A. F., Steffensen, Knut R., van Gilst, Wiek H., de Boer, Rudolf A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Berlin Heidelberg 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742491/
https://ncbi.nlm.nih.gov/pubmed/26684450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-015-3827-x
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