Dysregulated endocardial TGFβ signaling and mesenchymal transformation result in heart outflow tract septation failure

Heart outflow tract septation in mouse embryos carrying mutations in retinoic acid receptor genes fails with complete penetrance. In this mutant background, ectopic TGFβ signaling in the distal outflow tract is responsible for septation failure, but it was uncertain what tissue was responsive to ect...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Dev Biol
Asıl Yazarlar: Ma, Mancheong, Li, Peng, Shen, Hua, Estrada, Kristine D., Xu, Jian, Kumar, S. Ram, Sucov, Henry M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742370/
https://ncbi.nlm.nih.gov/pubmed/26522286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2015.09.021
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