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Dysregulated endocardial TGFβ signaling and mesenchymal transformation result in heart outflow tract septation failure
Heart outflow tract septation in mouse embryos carrying mutations in retinoic acid receptor genes fails with complete penetrance. In this mutant background, ectopic TGFβ signaling in the distal outflow tract is responsible for septation failure, but it was uncertain what tissue was responsive to ect...
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| Publicado no: | Dev Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4742370/ https://ncbi.nlm.nih.gov/pubmed/26522286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2015.09.021 |
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