Identification of novel, in vivo active Chk1 inhibitors utilizing structure guided drug design

Chk1 kinase is a critical component of the DNA damage response checkpoint especially in cancer cells and targeting Chk1 is a potential therapeutic opportunity for potentiating the anti-tumor activity of DNA damaging chemotherapy drugs. Fragment elaboration by structure guided design was utilized to...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Massey, Andrew J., Stokes, Stephen, Browne, Helen, Foloppe, Nicolas, Fiumana, Andreá, Scrace, Simon, Fallowfield, Mandy, Bedford, Simon, Webb, Paul, Baker, Lisa, Christie, Mark, Drysdale, Martin J., Wood, Mike
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742142/
https://ncbi.nlm.nih.gov/pubmed/26437226
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados