Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells

Ubiquitin-conjugating enzyme 9 (Ubc9) is required for sumoylation and inhibits apoptosis via Bcl-2 by unknown mechanism. Methionine adenosyltransferase 2A (MAT2A) encodes for MATα2, the catalytic subunit of the MATII isoenzyme that synthesizes S-adenosylmethionine (SAMe). Ubc9, Bcl-2 and MAT2A expre...

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Publicat a:Oncotarget
Autors principals: Tomasi, Maria Lauda, Ryoo, Minjung, Ramani, Komal, Tomasi, Ivan, Giordano, Pasquale, Mato, José M., Lu, Shelly C.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2015
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741959/
https://ncbi.nlm.nih.gov/pubmed/26416353
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