Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells

Glioblastoma Multiforme (GBM) is the most common and aggressive human brain tumor, associated with very poor survival despite surgery, radiotherapy and chemotherapy. The epidermal growth factor receptor (EGFR) and the platelet-derived growth factor receptor β (PDGFRβ) are hallmarks in GBM with drivi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Principais autores: Camorani, Simona, Crescenzi, Elvira, Colecchia, David, Carpentieri, Andrea, Amoresano, Angela, Fedele, Monica, Chiariello, Mario, Cerchia, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741949/
https://ncbi.nlm.nih.gov/pubmed/26461476
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