Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells

Glioblastoma Multiforme (GBM) is the most common and aggressive human brain tumor, associated with very poor survival despite surgery, radiotherapy and chemotherapy. The epidermal growth factor receptor (EGFR) and the platelet-derived growth factor receptor β (PDGFRβ) are hallmarks in GBM with drivi...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Camorani, Simona, Crescenzi, Elvira, Colecchia, David, Carpentieri, Andrea, Amoresano, Angela, Fedele, Monica, Chiariello, Mario, Cerchia, Laura
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741949/
https://ncbi.nlm.nih.gov/pubmed/26461476
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