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Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine signaling

Sertoli cells, the primary somatic cell in the seminiferous epithelium, provide the spermatogonial stem cell (SSC) microenvironment (niche) through physical support and the expression of paracrine factors. However, the regulatory mechanisms within the SSC niche, which is primarily controlled by Sert...

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Bibliografski detalji
Izdano u:Oncotarget
Glavni autori: Chen, Su-Ren, Tang, Ji-Xin, Cheng, Jin-Mei, Li, Jian, Jin, Cheng, Li, Xiao-Yu, Deng, Shou-Long, Zhang, Yan, Wang, Xiu-Xia, Liu, Yi-Xun
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741912/
https://ncbi.nlm.nih.gov/pubmed/26473289
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