Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine signaling

Sertoli cells, the primary somatic cell in the seminiferous epithelium, provide the spermatogonial stem cell (SSC) microenvironment (niche) through physical support and the expression of paracrine factors. However, the regulatory mechanisms within the SSC niche, which is primarily controlled by Sert...

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Pubblicato in:Oncotarget
Autori principali: Chen, Su-Ren, Tang, Ji-Xin, Cheng, Jin-Mei, Li, Jian, Jin, Cheng, Li, Xiao-Yu, Deng, Shou-Long, Zhang, Yan, Wang, Xiu-Xia, Liu, Yi-Xun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2015
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Research Paper: Pathology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741912/
https://ncbi.nlm.nih.gov/pubmed/26473289
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