Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage

Vascular hyporeactivity is one of the major causes responsible for refractory hypotension and associated mortality in severe hemorrhagic shock. Mitochondrial permeability transition (mPT) pore opening in arteriolar smooth muscle cells (ASMCs) is involved in the pathogenesis of vascular hyporeactivit...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Li, Pengyun, Meng, Xianzhong, Bian, Huining, Burns, Nana, Zhao, Ke-seng, Song, Rui
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Research Paper: Pathology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741911/
https://ncbi.nlm.nih.gov/pubmed/26473372
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