Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage

Vascular hyporeactivity is one of the major causes responsible for refractory hypotension and associated mortality in severe hemorrhagic shock. Mitochondrial permeability transition (mPT) pore opening in arteriolar smooth muscle cells (ASMCs) is involved in the pathogenesis of vascular hyporeactivit...

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Udgivet i:Oncotarget
Main Authors: Li, Pengyun, Meng, Xianzhong, Bian, Huining, Burns, Nana, Zhao, Ke-seng, Song, Rui
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper: Pathology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741911/
https://ncbi.nlm.nih.gov/pubmed/26473372
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