Ligand-based chemoinformatic discovery of a novel small molecule inhibitor targeting CDC25 dual specificity phosphatases and displaying in vitro efficacy against melanoma cells

CDC25 phosphatases are important regulators of the cell cycle and represent promising targets for anticancer drug discovery. We recently identified NSC 119915 as a new quinonoid CDC25 inhibitor with potent anticancer activity. In order to discover more active analogs of NSC 119915, we performed a ra...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncotarget
Egile Nagusiak: Capasso, Alessandra, Cerchia, Carmen, Di Giovanni, Carmen, Granato, Giuseppina, Albano, Francesco, Romano, Simona, De Vendittis, Emmanuele, Ruocco, Maria Rosaria, Lavecchia, Antonio
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Impact Journals LLC 2015
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741889/
https://ncbi.nlm.nih.gov/pubmed/26474275
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