LGR5 regulates pro-survival MEK/ERK and proliferative Wnt/β-catenin signalling in neuroblastoma

LGR5 is a marker of normal and cancer stem cells in various tissues where it functions as a receptor for R-spondins and increases canonical Wnt signalling amplitude. Here we report that LGR5 is also highly expressed in a subset of high grade neuroblastomas. Neuroblastoma is a clinically heterogenous...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Vieira, Gabriella Cunha, Chockalingam, S., Melegh, Zsombor, Greenhough, Alexander, Malik, Sally, Szemes, Marianna, Park, Ji Hyun, Kaidi, Abderrahmane, Zhou, Li, Catchpoole, Daniel, Morgan, Rhys, Bates, David O., Gabb, Peter J., Malik, Karim
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2015
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741879/
https://ncbi.nlm.nih.gov/pubmed/26517508
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