Cigarette side-stream smoke lung and bladder carcinogenesis: inducing mutagenic acrolein-DNA adducts, inhibiting DNA repair and enhancing anchorage-independent-growth cell transformation

Second-hand smoke (SHS) is associated with 20–30% of cigarette-smoke related diseases, including cancer. Majority of SHS (>80%) originates from side-stream smoke (SSS). Compared to mainstream smoke, SSS contains more tumorigenic polycyclic aromatic hydrocarbons and acrolein (Acr). We assessed SSS...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lee, Hyun-Wook, Wang, Hsiang-Tsui, Weng, Mao-wen, Chin, Chiu, Huang, William, Lepor, Herbert, Wu, Xue-Ru, Rom, William N., Chen, Lung-Chi, Tang, Moon-shong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741761/
https://ncbi.nlm.nih.gov/pubmed/26431382
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