Down-regulation of IKKβ expression in glioma-infiltrating microglia/macrophages is associated with defective inflammatory/immune gene responses in glioblastoma

Glioblastoma (GBM) is an aggressive malignancy associated with profound host immunosuppression. Microglia and macrophages infiltrating GBM acquire the pro-tumorigenic, M2 phenotype and support tumor invasion, proliferation, survival, angiogenesis and block immune responses both locally and systemati...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Mieczkowski, Jakub, Kocyk, Marta, Nauman, Pawel, Gabrusiewicz, Konrad, Sielska, Małgorzata, Przanowski, Piotr, Maleszewska, Marta, Rajan, Wenson D., Pszczolkowska, Dominika, Tykocki, Tomasz, Grajkowska, Wieslawa, Kotulska, Katarzyna, Roszkowski, Marcin, Kostkiewicz, Boguslaw, Kaminska, Bozena
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741750/
https://ncbi.nlm.nih.gov/pubmed/26427514
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