Novel Proteins Regulated by mTOR in Subependymal Giant Cell Astrocytomas of Patients with Tuberous Sclerosis Complex and New Therapeutic Implications

Subependymal giant cell astrocytomas (SEGAs) are rare brain tumors associated with tuberous sclerosis complex (TSC), a disease caused by mutations in TSC1 or TSC2, resulting in enhancement of mammalian target of rapamycin (mTOR) activity, dysregulation of cell growth, and tumorigenesis. Signaling vi...

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Detalhes bibliográficos
Main Authors: Tyburczy, Magdalena Ewa, Kotulska, Katarzyna, Pokarowski, Piotr, Mieczkowski, Jakub, Kucharska, Joanna, Grajkowska, Wieslawa, Roszkowski, Maciej, Jozwiak, Sergiusz, Kaminska, Bozena
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843477/
https://ncbi.nlm.nih.gov/pubmed/20133820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090950
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