Novel Proteins Regulated by mTOR in Subependymal Giant Cell Astrocytomas of Patients with Tuberous Sclerosis Complex and New Therapeutic Implications

Subependymal giant cell astrocytomas (SEGAs) are rare brain tumors associated with tuberous sclerosis complex (TSC), a disease caused by mutations in TSC1 or TSC2, resulting in enhancement of mammalian target of rapamycin (mTOR) activity, dysregulation of cell growth, and tumorigenesis. Signaling vi...

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Hlavní autoři: Tyburczy, Magdalena Ewa, Kotulska, Katarzyna, Pokarowski, Piotr, Mieczkowski, Jakub, Kucharska, Joanna, Grajkowska, Wieslawa, Roszkowski, Maciej, Jozwiak, Sergiusz, Kaminska, Bozena
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2010
Témata:
Regular Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843477/
https://ncbi.nlm.nih.gov/pubmed/20133820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090950
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