Characteristics of the Alternative Phenotype of Microglia/Macrophages and its Modulation in Experimental Gliomas

Microglia (brain resident macrophages) accumulate in malignant gliomas and instead of initiating the anti-tumor response, they switch to a pro-invasive phenotype, support tumor growth, invasion, angiogenesis and immunosuppression by release of cytokines/chemokines and extracellular matrix proteases....

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Bibliographic Details
Main Authors: Gabrusiewicz, Konrad, Ellert-Miklaszewska, Aleksandra, Lipko, Maciej, Sielska, Malgorzata, Frankowska, Marta, Kaminska, Bozena
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162015/
https://ncbi.nlm.nih.gov/pubmed/21901144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023902
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