Functional signaling pathway analysis of lung adenocarcinomas identifies novel therapeutic targets for KRAS mutant tumors

Little is known about the complex signaling architecture of KRAS and the interconnected RAS-driven protein-protein interactions, especially as it occurs in human clinical specimens. This study explored the activated and interconnected signaling network of KRAS mutant lung adenocarcinomas (AD) to ide...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Baldelli, Elisa, Bellezza, Guido, Haura, Eric B., Crinó, Lucio, Cress, W. Douglas, Deng, Jianghong, Ludovini, Vienna, Sidoni, Angelo, Schabath, Matthew B., Puma, Francesco, Vannucci, Jacopo, Siggillino, Annamaria, Liotta, Lance A., Petricoin, Emanuel F., Pierobon, Mariaelena
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2015
Sujets:
Priority Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741699/
https://ncbi.nlm.nih.gov/pubmed/26468985
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