Distinct breast cancer stem/progenitor cell populations require either HIF1α or loss of PHD3 to expand under hypoxic conditions

The heterogeneous nature of breast cancer is a result of intrinsic tumor complexity and also of the tumor microenvironment, which is known to be hypoxic. We found that hypoxia expands different breast stem/progenitor cell populations (cells with increased aldehyde dehydrogenase activity (Aldefluor(+...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Iriondo, Oihana, Rábano, Miriam, Domenici, Giacomo, Carlevaris, Onintza, López-Ruiz, José Antonio, Zabalza, Ignacio, Berra, Edurne, Vivanco, Maria dM
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741635/
https://ncbi.nlm.nih.gov/pubmed/26372732
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