A Sox2–Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells

Increased cancer stem cell content during development of resistance to tamoxifen in breast cancer is driven by multiple signals, including Sox2-dependent activation of Wnt signalling. Here, we show that Sox2 increases and estrogen reduces the expression of the transcription factor Sox9. Gain and los...

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Pubblicato in:Oncogene
Autori principali: Domenici, Giacomo, Aurrekoetxea-Rodríguez, Iskander, Simões, Bruno M., Rábano, Miriam, Lee, So Young, Millán, Julia San, Comaills, Valentine, Oliemuller, Erik, López-Ruiz, José A., Zabalza, Ignacio, Howard, Beatrice A., Kypta, Robert M., Vivanco, Maria dM
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6756022/
https://ncbi.nlm.nih.gov/pubmed/30622340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0656-7
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